Diagnostic Classification of Lung Cancer Using Deep Transfer Learning Technology and Multi-Omics Data

ZHU Rong; DAI Lingyun; LIU Jinxing; GUO Ying

doi:10.1049/cje.2021.06.006

Volume 30 Issue 5

Sep. 2021

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Article Navigation > Chinese Journal of Electronics > 2021 > 30(5): 843-852

ZHU Rong, DAI Lingyun, LIU Jinxing, et al., “Diagnostic Classification of Lung Cancer Using Deep Transfer Learning Technology and Multi-Omics Data,” Chinese Journal of Electronics, vol. 30, no. 5, pp. 843-852, 2021, doi: 10.1049/cje.2021.06.006

Citation:

ZHU Rong, DAI Lingyun, LIU Jinxing, et al., “Diagnostic Classification of Lung Cancer Using Deep Transfer Learning Technology and Multi-Omics Data,” Chinese Journal of Electronics, vol. 30, no. 5, pp. 843-852, 2021, doi: 10.1049/cje.2021.06.006

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Diagnostic Classification of Lung Cancer Using Deep Transfer Learning Technology and Multi-Omics Data

doi: 10.1049/cje.2021.06.006

1. School of Computer Science, Qufu Normal University, Rizhao 276826, China;
2. School of Automation, Central South University, Changsha 410083, China

Funds:

This work is supported in part by Shandong Social Science Planning Fund Program No. 21BTQJ02, and the National Natural Science Foundation of China under Grant No.61902215, No.61872220.

Received Date: 2020-09-28
Available Online: 2021-09-02

Abstract

Abstract

In recent years, with the increasing application of highthroughput sequencing technology, researchers have obtained and accumulated a large amount of multi-omics data, making it possible to diagnose cancer at the gene expression level. The proliferation of various omics data can provide a large amount of biological information, which brings new opportunities and great challenges as well to cancer classification and diagnosis. Machine learning algorithms for early diagnosis of lung cancer have emerged that distinguish cancers of the early and late stages by using genomic features. Omics data are generally characterized with low sample size, high dimensionality and high noise. Therefore, simple direct application of common classification methods cannot achieve better performance and must be improved in a targeted manner. This paper puts forward a combined convolutional neural network and convolutional autoencoders approach to construct a deep migratory learning classification model for early lung cancer diagnosis. First, the convolutional auto-encoders algorithm is used to reduce the dimensionality of the dataset in order to make it better meet the requirements of migration learning. Second, a neural network model is constructed with the original dataset and the existing labeled dataset, and the model migration rules are set as well. Finally, a small number of labeled target datasets are used in the training to complete the construction of the classification model. The proposed convolutional neural network method based on model migration and five other popular machine learning models are used to classify and predict the three lung cancer gene datasets and the integrated dataset. The experimental results show that such four evaluation metrics as accuracy, precision, recall, and f1-score with our proposed method have obtained better prediction performance, and the average area under curve result also shows our proposed method is optimal.
- Diagnostic classification,
- Deep transfer learning,
- Multiomics data,
- Lung cancer

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References(28)

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