Volume 30 Issue 5
Sep.  2021
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WANG Chao, ZOU Quan. A Machine Learning Method for Differentiating and Predicting Human-Infective Coronavirus Based on Physicochemical Features and Composition of the Spike Protein[J]. Chinese Journal of Electronics, 2021, 30(5): 815-823. doi: 10.1049/cje.2021.06.003
Citation: WANG Chao, ZOU Quan. A Machine Learning Method for Differentiating and Predicting Human-Infective Coronavirus Based on Physicochemical Features and Composition of the Spike Protein[J]. Chinese Journal of Electronics, 2021, 30(5): 815-823. doi: 10.1049/cje.2021.06.003

A Machine Learning Method for Differentiating and Predicting Human-Infective Coronavirus Based on Physicochemical Features and Composition of the Spike Protein

doi: 10.1049/cje.2021.06.003
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This paper is supported by the National Natural Science Foundation of China (No.61922020, No.61771331, No.62002051).

  • Received Date: 2020-09-11
    Available Online: 2021-09-02
  • Several Coronaviruses (CoVs) are epidemic pathogens that cause severe respiratory syndrome and are associated with significant morbidity and mortality. In this paper, a machine learning method was developed for predicting the risk of human infection posed by CoVs as an early warning system. The proposed Spike-SVM (Support vector machine) model achieved an accuracy of 97.36% for Human-infective CoV (HCoV) and Nonhuman-infective CoV (Non-HCoV) classification. The top informative features that discriminate HCoVs and Non-HCoVs were identified. Spike-SVM is anticipated to be a useful bioinformatics tool for predicting the infection risk posed by CoVs to humans.
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