A Millimeter-Wave Sensor and Differential Filter-Paper-Based Measurement Method for Cancer Cell Detections

LE Yi; LIU Hao; SU Guodong; LIU Jun; WANG Xiang; SUN Lingling

doi:10.23919/cje.2024.00.047

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Yi LE, Hao LIU, Guodong SU, et al., “A Millimeter-Wave Sensor and Differential Filter-Paper-Based Measurement Method for Cancer Cell Detections,” Chinese Journal of Electronics, vol. 34, no. 2, pp. 1–11, 2025 doi: 10.23919/cje.2024.00.047

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Yi LE, Hao LIU, Guodong SU, et al., “A Millimeter-Wave Sensor and Differential Filter-Paper-Based Measurement Method for Cancer Cell Detections,” Chinese Journal of Electronics, vol. 34, no. 2, pp. 1–11, 2025 doi: 10.23919/cje.2024.00.047

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A Millimeter-Wave Sensor and Differential Filter-Paper-Based Measurement Method for Cancer Cell Detections

doi: 10.23919/cje.2024.00.047

1.
Innovation Center for Electronic Design Automation Technology, Hangzhou Dianzi University, Hangzhou 310018, China

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Author Bio:
Yi LE was born in Ningbo, Zhejiang, in 2003. He is currently pursuing a B.S. degree in electronic and information engineering at Hangzhou Dianzi University.In 2021, he joined the Zhejiang Provincial Laboratory of Integrated Circuit Design to assist professors in their research. In 2022, he was awarded the Zhejiang Provincial Government Scholarship. His current research interests include microwave and millimeter-wave filters and biosensors. (Email: 1720037175@qq.com)

Hao LIU was born in Hangzhou, Zhejiang, in 1998. He received the B.S. degree in integrated circuit design from Hangzhou Dianzi University, in 2017. He is currently pursuing the M.S. degree in Electronic Information from Hangzhou Dianzi University, Hangzhou, Zhejiang.His current research interests include the designs of monolithic microwave-integrated circuit. (Email: 1145457712@qq.com)

Guodong SU received the B.S. and M.S. degrees from Hangzhou Dianzi University, Hangzhou, China, in 2007 and 2012, respectively, and the Ph.D. degree from Zhejiang University, Hangzhou, in 2018.Since 2018, he has been an Assistant Professor with the Key Laboratory of RF Circuits and Systems, Ministry of China, Hangzhou Dianzi University. His current research interests include mm-wave and THz integrated circuit design and monolithic microwave-integrated circuit design. (Email: guodong@hdu.edu.cn)

Jun LIU received the M.E. degree in circuits and systems from Hangzhou Dianzi University, Hangzhou, China, in 2006, and the Ph.D. degree in electronic engineering from Dublin City University, Dublin, Ireland, in 2011. He is currently a Research Professor with the Key Laboratory for RF Circuits and Systems of Ministry of Education, Hangzhou Dianzi University.His current research interests include characterization of millimeter- and submillimeter-wave semiconductor devices, integrated circuits design method, and measurement technique development. (Email: ljun77@hdu.edu.cn)

Xiang WANG received the B.E. and Ph.D. degrees in electronic science and technology from Zhejiang University, Hangzhou, China, in June 2007 and June 2012, respectively. In June 2012, he joined the School of Electronics and Information, Hangzhou Dianzi University, Hangzhou, where he has been a Lecturer.His primary research interests include the characterization and modeling of active and passive devices, novel design, and device optimization for millimeter-wave applications. (Email: jimmywangx@163.com)

Lingling SUN received the B.S. degree from the Nanjing University of Posts and Telecommunications, Nanjing, China, in 1982, and the M.S. degree from the University of Electronic Science and Technology, Chengdu, China, in 1985.She then joined the Electronics and Information Department, Hangzhou Dianzi University (HDU), Hangzhou, China. She is currently the Director at the Key Laboratory of RF Circuits and Systems, Ministry of Education, HDU. She was principal investigator for over 40 national projects funded by national “863” and ”973” projects, NSFC. She has published over 80 papers at international peer-reviewed journals and conferences. Her major research interests include the design and CAD of RF/microwave integrated circuits (ICs) and systems. She is also very interested in the development of the smart hardware systems and medical electronic equipment areas. (Email: llsun@hdu.edu.cn)
Corresponding author: Email: jimmywangx@163.com
Available Online: 2024-06-15

Abstract

Abstract

This paper introduces a novel, easily-designed millimeter-wave sensor and an innovative liquid sensing method, both suitable for biological sample detection and cancer cell discrimination. The sensor, composed of coplanar waveguides with load resonators, features a centrally symmetric stepped-impedance resonator that creates a detection region, capable of achieving multiple transmission poles and zeros. This resonator is responsive to the equivalent dielectric constant of the surrounding space, mirroring the electromagnetic properties of the tested sample via the resonant frequency and notch depth. The proposed sensing method uses filter paper to characterize a liquid’s electromagnetic properties by comparing the s-parameters of dry and wet filter paper loaded onto the sensor. This method, an alternative to traditional microfluidic channels, allows all planar microwave/millimeter-wave solid dielectric constant sensors to robustly detect liquid materials. Applied to biomedicine, the design enables the sensor to generate multiple transmission peaks in the 20–60 GHz range, thereby facilitating discrimination of various cancer cell culture media and suspensions. Compared to traditional biochemical methods, this approach significantly reduces cancer detection costs and offers new avenues for label-free, real-time detection.
- Millimeter waves,
- biosensors,
- coplanar waveguide,
- differential filter-paper-based measurement

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References(46)

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