WANG Xuesong, LIU Qingfeng, CHENG Yuhu, LI Lijing. Qualitative Analysis of Gene Regulatory Networks Based on Angular Discretization[J]. Chinese Journal of Electronics, 2011, 20(4): 646-650.
Citation: WANG Xuesong, LIU Qingfeng, CHENG Yuhu, LI Lijing. Qualitative Analysis of Gene Regulatory Networks Based on Angular Discretization[J]. Chinese Journal of Electronics, 2011, 20(4): 646-650.

Qualitative Analysis of Gene Regulatory Networks Based on Angular Discretization

  • Received Date: 2010-09-01
  • Rev Recd Date: 2010-10-01
  • Publish Date: 2011-10-25
  • It is well known that there is a hypothesis in the analysis of gene regulatory networks, i:e., if two genes expression profiles change in a similar trend, a regulatory relationship may exists in these two genes. Therefore, the use of angular discretization to deal with gene expression data can reflect the changes of gene expression values in tendency and intensity, which makes it possible to analyze the regulatory relationship between genes qualitatively. At first, we draw a line between the neighboring gene expression data. Thus an angle between the connected line and a horizontal line is formed. Secondly, according to the de- fined rules of angular discretization, we discretize the angle into six states by carrying out several times of discretization operation. The six states reflect not only the trend but also the change degree of gene expression values. In the end, the genes having regulatory relationships will be identified by using the substruction and the relative frequency methods. Experimental results concerning on the Saccharomyces microarray dataset verify the validity of the proposed method.
  • loading
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (543) PDF downloads(717) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return