Large-scale parallel simulation applications, characterized by complex computation, vast amount of data, great storage, large quantities of samples and strong causality, can only be realized by employing highperformance simulation supercomputer. This paper proposes the idea of “blending the general and the specialized” in developing high-performance simulation supercomputer, in which various functions are enhanced, such as the compute node, specialized simulation synchronization network, globally shared I/O, and visualization system, based on the general supercomputer. The disadvantages of the HLA standard are also analyzed and the necessity is explained to develop the efficient parallel simulation infrastructure according to the characteristics of the highperformance simulation supercomputer. This paper also presents the experimental results of large-scale simulation applications running in our high-performance simulation supercomputer. As shown by such results, the execution efficiency is greatly improved in large-scale parallel simulation applications with enhanced high-performance simulation supercomputer and customized parallel simulation infrastructure.